Drug interactions
Gemifloxacin + Ipratropium-salbutamol
Severity: Moderate
Gemifloxacin and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin is a fluoroquinolone that can prolong the QT interval. Salbutamol may contribute through tachycardia and hypokalemia, which raise the risk of torsades de pointes. The risk is greater with high-dose salbutamol or underlying cardiac disease.
What this interaction means in plain words
Gemifloxacin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia increasing proarrhythmic susceptibility.
What to do
Check and correct potassium and magnesium, and consider an ECG in patients with cardiac risk factors. Limit salbutamol use or choose a non-QT-prolonging antibiotic when risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Gemifloxacin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin is a fluoroquinolone that can prolong the QT interval. Salbutamol may contribute through tachycardia and hypokalemia, which raise the risk of torsades de pointes. The risk is greater with high-dose salbutamol or underlying cardiac disease.
How serious is the interaction between Gemifloxacin and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium, and consider an ECG in patients with cardiac risk factors. Limit salbutamol use or choose a non-QT-prolonging antibiotic when risk is high.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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