Drug interactions
Gemifloxacin + Ketoprofen
Severity: Moderate
Gemifloxacin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones, mainly in predisposed patients. Absolute risk is low but a seizure is clinically serious.
What this interaction means in plain words
Gemifloxacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Ketoprofen belongs to Musculoskeletal.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding may be potentiated by NSAIDs; mechanism not fully established.
What to do
Avoid in patients with epilepsy or lowered seizure threshold; otherwise monitor for CNS symptoms and stop gemifloxacin if seizures or marked agitation occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ketoprofen?
MediHelp rates the interaction as moderate. Gemifloxacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones, mainly in predisposed patients. Absolute risk is low but a seizure is clinically serious.
How serious is the interaction between Gemifloxacin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or lowered seizure threshold; otherwise monitor for CNS symptoms and stop gemifloxacin if seizures or marked agitation occur.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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