Drug interactions
Gemifloxacin + Prednisone
Severity: Major
Gemifloxacin and Prednisone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones combined with systemic corticosteroids increase the risk of tendinitis and tendon rupture, most often the Achilles tendon. Risk is higher in older patients and transplant recipients.
What this interaction means in plain words
Gemifloxacin and Prednisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Prednisone belongs to Endocrine.
Why it happens
Additive tendon toxicity, with fluoroquinolone effects on tenocytes and collagen and corticosteroid inhibition of collagen synthesis.
What to do
Avoid the combination when an alternative antibiotic is suitable, especially in patients over 60. Stop the fluoroquinolone and rest the limb if tendon pain develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Prednisone?
MediHelp rates the interaction as major. Gemifloxacin and Prednisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones combined with systemic corticosteroids increase the risk of tendinitis and tendon rupture, most often the Achilles tendon. Risk is higher in older patients and transplant recipients.
How serious is the interaction between Gemifloxacin and Prednisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative antibiotic is suitable, especially in patients over 60. Stop the fluoroquinolone and rest the limb if tendon pain develops.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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