Drug interactions
Gemifloxacin + Quetiapine
Severity: Moderate
Gemifloxacin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine and gemifloxacin can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is greater with overdose, electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Gemifloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarisation effects.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT or other major risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Gemifloxacin with Quetiapine?
MediHelp rates the interaction as moderate. Gemifloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine and gemifloxacin can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is greater with overdose, electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Gemifloxacin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT or other major risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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