Drug interactions
Gemifloxacin + Repaglinide
Severity: Moderate
Gemifloxacin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause hypoglycemia or hyperglycemia in patients on antidiabetic drugs. With repaglinide, an insulin secretagogue, hypoglycemia may be more likely.
What this interaction means in plain words
Gemifloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, which adds to the insulin-secreting effect of repaglinide.
What to do
Monitor blood glucose closely during and after the antibiotic course and educate the patient on hypoglycemia symptoms. Reduce the repaglinide dose or change the antibiotic if glucose is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Gemifloxacin with Repaglinide?
MediHelp rates the interaction as moderate. Gemifloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause hypoglycemia or hyperglycemia in patients on antidiabetic drugs. With repaglinide, an insulin secretagogue, hypoglycemia may be more likely.
How serious is the interaction between Gemifloxacin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after the antibiotic course and educate the patient on hypoglycemia symptoms. Reduce the repaglinide dose or change the antibiotic if glucose is unstable.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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