Drug interactions
Gemifloxacin + Sulindac
Severity: Moderate
Gemifloxacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower the seizure threshold, and NSAIDs may potentiate this effect in susceptible patients. The risk is small but is relevant in those with epilepsy, CNS disease, renal impairment or high fluoroquinolone exposure.
What this interaction means in plain words
Gemifloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, which may be enhanced by NSAIDs; the mechanism is incompletely established.
What to do
Avoid the combination in patients with a seizure history or other risk factors for seizures. Otherwise monitor for neurological symptoms and stop the fluoroquinolone if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Sulindac?
MediHelp rates the interaction as moderate. Gemifloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower the seizure threshold, and NSAIDs may potentiate this effect in susceptible patients. The risk is small but is relevant in those with epilepsy, CNS disease, renal impairment or high fluoroquinolone exposure.
How serious is the interaction between Gemifloxacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other risk factors for seizures. Otherwise monitor for neurological symptoms and stop the fluoroquinolone if they occur.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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