Drug interactions
Gemifloxacin + Vardenafil
Severity: Moderate
Gemifloxacin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin can prolong the QT interval and vardenafil may add a small effect. The combination may raise the risk of torsades de pointes in patients with additional risk factors.
What this interaction means in plain words
Gemifloxacin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization via potassium channel effects.
What to do
Consider an alternative antibiotic in patients with QT risk factors, and correct electrolyte disturbances. Obtain an ECG if the combination is necessary in a high-risk patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Vardenafil?
MediHelp rates the interaction as moderate. Gemifloxacin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin can prolong the QT interval and vardenafil may add a small effect. The combination may raise the risk of torsades de pointes in patients with additional risk factors.
How serious is the interaction between Gemifloxacin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors, and correct electrolyte disturbances. Obtain an ECG if the combination is necessary in a high-risk patient.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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