Drug interactions
Gemifloxacin + Voclosporin
Severity: Moderate
Gemifloxacin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may prolong the QT interval at supratherapeutic exposures, and gemifloxacin has a known QT effect. The combination may add to the risk of serious arrhythmia.
What this interaction means in plain words
Gemifloxacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check an ECG and electrolytes before and during combined use. Prefer an antibiotic without QT liability in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Voclosporin?
MediHelp rates the interaction as moderate. Gemifloxacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin may prolong the QT interval at supratherapeutic exposures, and gemifloxacin has a known QT effect. The combination may add to the risk of serious arrhythmia.
How serious is the interaction between Gemifloxacin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes before and during combined use. Prefer an antibiotic without QT liability in patients with cardiac risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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