Drug interactions
Gemifloxacin + Warfarin
Severity: Moderate
Gemifloxacin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones have been reported to increase the anticoagulant effect of warfarin and raise the INR, which may lead to bleeding. The effect varies between patients and is also influenced by the underlying infection.
What this interaction means in plain words
Gemifloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Possible reduction of vitamin K-producing gut flora and displacement or reduced metabolism of warfarin; the mechanism is not fully established.
What to do
Check the INR within a few days of starting gemifloxacin and again after stopping it. Adjust the warfarin dose according to the INR and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Gemifloxacin with Warfarin?
MediHelp rates the interaction as moderate. Gemifloxacin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones have been reported to increase the anticoagulant effect of warfarin and raise the INR, which may lead to bleeding. The effect varies between patients and is also influenced by the underlying infection.
How serious is the interaction between Gemifloxacin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR within a few days of starting gemifloxacin and again after stopping it. Adjust the warfarin dose according to the INR and watch for bleeding.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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