Drug interactions
Gemtuzumab + Leuprolide
Severity: Moderate
Gemtuzumab and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and leuprolide may add to this effect. The combination can increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Gemtuzumab and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes during combined use. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Gemtuzumab with Leuprolide?
MediHelp rates the interaction as moderate. Gemtuzumab and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and leuprolide may add to this effect. The combination can increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Gemtuzumab and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during combined use. Correct potassium and magnesium abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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