Drug interactions
Gentamicin + Hydrochlorothiazide-losartan
Severity: Major
Gentamicin and Hydrochlorothiazide-losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic and can cause renal potassium and magnesium wasting. Thiazide diuretics and ARB-related reductions in renal perfusion can add to the kidney injury and electrolyte disturbance, and diuretics may increase ototoxicity risk.
What this interaction means in plain words
Gentamicin and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive nephrotoxicity and electrolyte loss, with diuretic-related volume depletion and ARB-reduced glomerular filtration.
What to do
Monitor creatinine, potassium, magnesium and gentamicin levels. Consider temporarily holding the diuretic and ARB during acute illness or prolonged aminoglycoside courses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Gentamicin and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin is nephrotoxic and can cause renal potassium and magnesium wasting. Thiazide diuretics and ARB-related reductions in renal perfusion can add to the kidney injury and electrolyte disturbance, and diuretics may increase ototoxicity risk.
How serious is the interaction between Gentamicin and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium, magnesium and gentamicin levels. Consider temporarily holding the diuretic and ARB during acute illness or prolonged aminoglycoside courses.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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