Drug interactions
Gentamicin + Irbesartan
Severity: Moderate
Gentamicin and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can reduce glomerular filtration, especially in volume-depleted patients, which may raise gentamicin exposure and nephrotoxicity risk. Potassium changes can also occur with renal impairment.
What this interaction means in plain words
Gentamicin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Irbesartan belongs to Cardiovascular.
Why it happens
Angiotensin II receptor blockade lowers glomerular filtration pressure, which may reduce aminoglycoside clearance and add to renal injury risk.
What to do
Monitor serum creatinine, potassium and gentamicin levels, and ensure adequate hydration. Consider holding the ARB if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Gentamicin with Irbesartan?
MediHelp rates the interaction as moderate. Gentamicin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can reduce glomerular filtration, especially in volume-depleted patients, which may raise gentamicin exposure and nephrotoxicity risk. Potassium changes can also occur with renal impairment.
How serious is the interaction between Gentamicin and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and gentamicin levels, and ensure adequate hydration. Consider holding the ARB if renal function worsens.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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