Drug interactions
Gentamicin + Ketoprofen
Severity: Moderate
Gentamicin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can impair kidney function, and NSAIDs reduce renal clearance of aminoglycosides, which may raise gentamicin concentrations. This increases the risk of nephrotoxicity and ototoxicity, especially in older or dehydrated patients.
What this interaction means in plain words
Gentamicin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and gentamicin clearance, adding to direct aminoglycoside tubular toxicity.
What to do
Monitor serum creatinine and gentamicin trough levels and ensure adequate hydration. Avoid the NSAID where possible during aminoglycoside therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Ketoprofen?
MediHelp rates the interaction as moderate. Gentamicin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can impair kidney function, and NSAIDs reduce renal clearance of aminoglycosides, which may raise gentamicin concentrations. This increases the risk of nephrotoxicity and ototoxicity, especially in older or dehydrated patients.
How serious is the interaction between Gentamicin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels and ensure adequate hydration. Avoid the NSAID where possible during aminoglycoside therapy.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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