Drug interactions
Gentamicin + Quinidine
Severity: Minor
Gentamicin and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein, and a theoretical rise in gentamicin exposure has been suggested. Aminoglycosides are mainly cleared by glomerular filtration and are poorly absorbed orally, so the clinical relevance is unclear. No well-documented harm has been shown.
What this interaction means in plain words
Gentamicin and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gentamicin belongs to Anti Bacterial; Quinidine belongs to Anti Parasitic.
Why it happens
Possible P-glycoprotein inhibition by quinidine; clinical relevance not established.
What to do
No routine change needed; follow standard gentamicin level and renal monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Gentamicin with Quinidine?
MediHelp rates the interaction as minor. Gentamicin and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein, and a theoretical rise in gentamicin exposure has been suggested. Aminoglycosides are mainly cleared by glomerular filtration and are poorly absorbed orally, so the clinical relevance is unclear. No well-documented harm has been shown.
How serious is the interaction between Gentamicin and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; follow standard gentamicin level and renal monitoring.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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