Drug interactions
Gentamicin + Rimabotulinumtoxinb
Severity: Moderate
Gentamicin and Rimabotulinumtoxinb: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and may potentiate the effect of botulinum toxin. This may cause excessive or generalized muscle weakness, including swallowing or breathing difficulty.
What this interaction means in plain words
Gentamicin and Rimabotulinumtoxinb can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Rimabotulinumtoxinb belongs to Musculoskeletal.
Why it happens
Additive impairment of neuromuscular transmission, presynaptic acetylcholine release inhibition by toxin plus aminoglycoside neuromuscular blockade.
What to do
Avoid giving aminoglycosides around the time of botulinum toxin treatment when possible; otherwise monitor for generalized weakness, dysphagia and respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Rimabotulinumtoxinb
- Amikacin + Rimabotulinumtoxinb Moderate
- Amitriptyline + Rimabotulinumtoxinb Moderate
- Atracurium + Rimabotulinumtoxinb Moderate
- Atropine + Rimabotulinumtoxinb Moderate
- Baclofen + Rimabotulinumtoxinb Moderate
- Benztropine + Rimabotulinumtoxinb Moderate
Frequently asked questions
Can I take Gentamicin with Rimabotulinumtoxinb?
MediHelp rates the interaction as moderate. Gentamicin and Rimabotulinumtoxinb can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can impair neuromuscular transmission and may potentiate the effect of botulinum toxin. This may cause excessive or generalized muscle weakness, including swallowing or breathing difficulty.
How serious is the interaction between Gentamicin and Rimabotulinumtoxinb?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving aminoglycosides around the time of botulinum toxin treatment when possible; otherwise monitor for generalized weakness, dysphagia and respiratory compromise.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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