Drug interactions
Gentamicin + Sulindac
Severity: Moderate
Gentamicin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise gentamicin serum levels, increasing the risk of nephrotoxicity and possibly ototoxicity. The risk is higher with dehydration, older age or pre-existing kidney disease.
What this interaction means in plain words
Gentamicin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and clearance, adding to aminoglycoside nephrotoxicity.
What to do
Monitor serum creatinine and gentamicin trough levels and ensure adequate hydration. Avoid the NSAID where renal function is already impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Sulindac?
MediHelp rates the interaction as moderate. Gentamicin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise gentamicin serum levels, increasing the risk of nephrotoxicity and possibly ototoxicity. The risk is higher with dehydration, older age or pre-existing kidney disease.
How serious is the interaction between Gentamicin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels and ensure adequate hydration. Avoid the NSAID where renal function is already impaired.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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