Drug interactions
Gentamicin + Tolfenamic acid
Severity: Moderate
Gentamicin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-mediated perfusion and can impair kidney function, which lowers gentamicin clearance and raises serum levels. This increases the risk of aminoglycoside nephrotoxicity and ototoxicity.
What this interaction means in plain words
Gentamicin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration decreases aminoglycoside elimination and adds to nephrotoxic risk.
What to do
Avoid NSAIDs where possible during gentamicin therapy; if needed, monitor serum creatinine and gentamicin trough levels and ensure hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Gentamicin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Gentamicin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin-mediated perfusion and can impair kidney function, which lowers gentamicin clearance and raises serum levels. This increases the risk of aminoglycoside nephrotoxicity and ototoxicity.
How serious is the interaction between Gentamicin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during gentamicin therapy; if needed, monitor serum creatinine and gentamicin trough levels and ensure hydration.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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