Drug interactions
Gepirone + Imipramine
Severity: Major
Gepirone and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both imipramine and gepirone enhance serotonergic activity, so combining them raises the risk of serotonin syndrome. Gepirone is also metabolised by CYP3A4 and imipramine has cardiac effects, with gepirone itself carrying QT prolongation risk.
What this interaction means in plain words
Gepirone and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gepirone belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity, plus additive QT prolongation potential.
What to do
Avoid combining where possible. If used together, monitor for serotonin syndrome and ECG changes, and stop one agent if symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Imipramine?
MediHelp rates the interaction as major. Gepirone and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both imipramine and gepirone enhance serotonergic activity, so combining them raises the risk of serotonin syndrome. Gepirone is also metabolised by CYP3A4 and imipramine has cardiac effects, with gepirone itself carrying QT prolongation risk.
How serious is the interaction between Gepirone and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor for serotonin syndrome and ECG changes, and stop one agent if symptoms occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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