Drug interactions
Gepirone + Paroxetine
Severity: Major
Gepirone and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonergic antidepressant, and combining it with paroxetine increases the risk of serotonin syndrome. Paroxetine is also a CYP2D6 inhibitor and may affect gepirone disposition.
What this interaction means in plain words
Gepirone and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gepirone belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity (5-HT1A agonism plus reuptake inhibition).
What to do
Avoid concurrent antidepressant use where possible, as gepirone is not intended to be combined with another SSRI. If unavoidable, monitor for serotonin syndrome and stop one agent if it develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Paroxetine?
MediHelp rates the interaction as major. Gepirone and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone is a serotonergic antidepressant, and combining it with paroxetine increases the risk of serotonin syndrome. Paroxetine is also a CYP2D6 inhibitor and may affect gepirone disposition.
How serious is the interaction between Gepirone and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent antidepressant use where possible, as gepirone is not intended to be combined with another SSRI. If unavoidable, monitor for serotonin syndrome and stop one agent if it develops.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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