Drug interactions
Gepirone + Quinine
Severity: Major
Gepirone and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and gepirone prolong the QTc interval, so combining them raises the risk of torsades de pointes. Quinine as a CYP3A4 inhibitor may also raise gepirone levels, further increasing the QT effect.
What this interaction means in plain words
Gepirone and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gepirone belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by quinine increasing gepirone exposure.
What to do
Avoid the combination where possible, and obtain a baseline ECG and electrolytes if it is necessary. Monitor the QTc and reduce the gepirone dose if a CYP3A4 inhibitor effect is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Quinine?
MediHelp rates the interaction as major. Gepirone and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both quinine and gepirone prolong the QTc interval, so combining them raises the risk of torsades de pointes. Quinine as a CYP3A4 inhibitor may also raise gepirone levels, further increasing the QT effect.
How serious is the interaction between Gepirone and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and obtain a baseline ECG and electrolytes if it is necessary. Monitor the QTc and reduce the gepirone dose if a CYP3A4 inhibitor effect is suspected.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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