Drug interactions
Gepirone + Rasagiline
Severity: Contraindicated
Gepirone and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is contraindicated with MAO inhibitors because of the risk of serotonin syndrome. This applies during therapy and for 14 days after an MAO inhibitor is stopped.
What this interaction means in plain words
Gepirone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Gepirone is a 5-HT1A agonist, and MAO inhibition raises serotonin levels, producing additive serotonergic activity.
What to do
Do not combine; wait at least 14 days after stopping an MAO inhibitor before starting gepirone, and 14 days after stopping gepirone before an MAO inhibitor.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Rasagiline?
MediHelp rates the interaction as contraindicated. Gepirone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is contraindicated with MAO inhibitors because of the risk of serotonin syndrome. This applies during therapy and for 14 days after an MAO inhibitor is stopped.
How serious is the interaction between Gepirone and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; wait at least 14 days after stopping an MAO inhibitor before starting gepirone, and 14 days after stopping gepirone before an MAO inhibitor.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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