Drug interactions
Gepirone + Safinamide
Severity: Contraindicated
Gepirone and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonin 5-HT1A agonist antidepressant whose labeling contraindicates use with MAO inhibitors. Combining it with safinamide risks serotonin syndrome, with agitation, hyperthermia, neuromuscular hyperactivity and autonomic instability.
What this interaction means in plain words
Gepirone and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
MAO inhibition elevates serotonin levels, adding to the serotonergic activity of gepirone.
What to do
Do not co-administer. Observe a washout of at least 14 days after stopping an MAOI before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Safinamide?
MediHelp rates the interaction as contraindicated. Gepirone and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is a serotonin 5-HT1A agonist antidepressant whose labeling contraindicates use with MAO inhibitors. Combining it with safinamide risks serotonin syndrome, with agitation, hyperthermia, neuromuscular hyperactivity and autonomic instability.
How serious is the interaction between Gepirone and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Observe a washout of at least 14 days after stopping an MAOI before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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