Drug interactions
Gepirone + Sorafenib
Severity: Moderate
Gepirone and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sorafenib and gepirone can prolong the QT interval, so using them together may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Gepirone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Sorafenib?
MediHelp rates the interaction as moderate. Gepirone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both sorafenib and gepirone can prolong the QT interval, so using them together may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Gepirone and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc becomes markedly prolonged.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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