Drug interactions
Gilteritinib + Memantine-donepezil
Severity: Moderate
Gilteritinib and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and gilteritinib can prolong the QT interval. Their combined use raises the risk of clinically significant QT prolongation and torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Gilteritinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization via QT prolongation.
What to do
Perform ECG monitoring at baseline and during therapy, and correct hypokalemia and hypomagnesemia. Consider interrupting or reducing the dose of gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Memantine-donepezil?
MediHelp rates the interaction as moderate. Gilteritinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and gilteritinib can prolong the QT interval. Their combined use raises the risk of clinically significant QT prolongation and torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Gilteritinib and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and during therapy, and correct hypokalemia and hypomagnesemia. Consider interrupting or reducing the dose of gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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