Drug interactions
Gilteritinib + Mifepristone
Severity: Major
Gilteritinib and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is a CYP3A4 substrate, so strong inhibition raises its exposure and toxicity. Both drugs also prolong the QT interval, compounding the risk of arrhythmia.
What this interaction means in plain words
Gilteritinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 and both drugs additively prolong QT.
What to do
Use an alternative to mifepristone where possible. If combined, monitor ECGs, electrolytes and adverse effects, and reduce or interrupt gilteritinib for serious toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Mifepristone?
MediHelp rates the interaction as major. Gilteritinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib is a CYP3A4 substrate, so strong inhibition raises its exposure and toxicity. Both drugs also prolong the QT interval, compounding the risk of arrhythmia.
How serious is the interaction between Gilteritinib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to mifepristone where possible. If combined, monitor ECGs, electrolytes and adverse effects, and reduce or interrupt gilteritinib for serious toxicity.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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