Drug interactions
Gilteritinib + Mitoxantrone
Severity: Moderate
Gilteritinib and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib may inhibit BCRP and P-gp, which could raise mitoxantrone exposure. This may increase myelosuppression and cardiotoxicity, and the two drugs are often used together in relapsed AML regimens.
What this interaction means in plain words
Gilteritinib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP/P-gp efflux transporters by gilteritinib may decrease mitoxantrone clearance.
What to do
Monitor blood counts and cardiac function (including LVEF) closely during combined use. Adjust mitoxantrone dosing according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Gilteritinib with Mitoxantrone?
MediHelp rates the interaction as moderate. Gilteritinib and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib may inhibit BCRP and P-gp, which could raise mitoxantrone exposure. This may increase myelosuppression and cardiotoxicity, and the two drugs are often used together in relapsed AML regimens.
How serious is the interaction between Gilteritinib and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function (including LVEF) closely during combined use. Adjust mitoxantrone dosing according to toxicity.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
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