Drug interactions
Gilteritinib + Primaquine
Severity: Major
Gilteritinib and Primaquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is associated with QT prolongation and torsades de pointes, and primaquine may add to this effect. Patients with leukemia often have electrolyte disturbances and other risk factors that increase the danger.
What this interaction means in plain words
Gilteritinib and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform an ECG at baseline and regularly during therapy, and correct potassium and magnesium. Consider an alternative antimalarial or hold the interacting drug if QTc increases markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Primaquine?
MediHelp rates the interaction as major. Gilteritinib and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib is associated with QT prolongation and torsades de pointes, and primaquine may add to this effect. Patients with leukemia often have electrolyte disturbances and other risk factors that increase the danger.
How serious is the interaction between Gilteritinib and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform an ECG at baseline and regularly during therapy, and correct potassium and magnesium. Consider an alternative antimalarial or hold the interacting drug if QTc increases markedly.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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