Drug interactions
Gilteritinib + Ritonavir
Severity: Major
Gilteritinib and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A and P-glycoprotein and can raise gilteritinib exposure. Higher levels may increase toxicities such as QT prolongation, differentiation syndrome, hepatotoxicity and myelosuppression.
What this interaction means in plain words
Gilteritinib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-gp by ritonavir reduces gilteritinib clearance and increases its absorption.
What to do
Prefer an alternative antiretroviral or booster-free regimen where possible. If combined, monitor ECG, electrolytes, liver tests and signs of toxicity closely, and consider gilteritinib dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Gilteritinib with Ritonavir?
MediHelp rates the interaction as major. Gilteritinib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A and P-glycoprotein and can raise gilteritinib exposure. Higher levels may increase toxicities such as QT prolongation, differentiation syndrome, hepatotoxicity and myelosuppression.
How serious is the interaction between Gilteritinib and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiretroviral or booster-free regimen where possible. If combined, monitor ECG, electrolytes, liver tests and signs of toxicity closely, and consider gilteritinib dose reduction.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
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