Drug interactions
Gilteritinib + Sertraline
Severity: Moderate
Gilteritinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib's activity depends partly on 5-HT2B and sigma receptor binding, and drugs that bind these targets may blunt its effect. Sertraline binds the sigma-1 receptor, so there is a theoretical reduction in gilteritinib efficacy. Gilteritinib does not clearly lower sertraline levels, so the legacy direction is doubtful. Sertraline and gilteritinib both have QT effects.
What this interaction means in plain words
Gilteritinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Possible pharmacodynamic antagonism at sigma receptors and additive QT prolongation, which is not well established.
What to do
Consider an antidepressant with less sigma-receptor activity if one is appropriate. Otherwise monitor the ECG and the leukemia response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Sertraline?
MediHelp rates the interaction as moderate. Gilteritinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib's activity depends partly on 5-HT2B and sigma receptor binding, and drugs that bind these targets may blunt its effect. Sertraline binds the sigma-1 receptor, so there is a theoretical reduction in gilteritinib efficacy. Gilteritinib does not clearly lower sertraline levels, so the legacy direction is doubtful. Sertraline and gilteritinib both have QT effects.
How serious is the interaction between Gilteritinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antidepressant with less sigma-receptor activity if one is appropriate. Otherwise monitor the ECG and the leukemia response.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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