Drug interactions
Gilteritinib + Umeclidinium-vilanterol
Severity: Moderate
Gilteritinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval and vilanterol may add to this effect. The combination may increase the risk of arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Gilteritinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG and keep potassium and magnesium within normal range. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Gilteritinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib can prolong the QT interval and vilanterol may add to this effect. The combination may increase the risk of arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Gilteritinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range. Review other QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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