Drug interactions
Givinostat + Goserelin
Severity: Moderate
Givinostat and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and goserelin may contribute. Combined use raises the risk of serious ventricular arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Givinostat and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain ECGs at initiation and during concurrent use. Withhold givinostat if QTc exceeds 500 ms or rises substantially from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Givinostat and Goserelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Goserelin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Goserelin?
MediHelp rates the interaction as moderate. Givinostat and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and goserelin may contribute. Combined use raises the risk of serious ventricular arrhythmia, particularly with other risk factors.
How serious is the interaction between Givinostat and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during concurrent use. Withhold givinostat if QTc exceeds 500 ms or rises substantially from baseline.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
