Drug interactions
Givinostat + Sevoflurane
Severity: Major
Givinostat and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and its labeling advises caution with other QT-prolonging drugs. Sevoflurane adds to this effect and may raise the risk of torsades de pointes.
What this interaction means in plain words
Givinostat and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG before anesthesia and keep potassium and magnesium within normal range. Monitor the ECG during and after anesthesia, and withhold givinostat if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Sevoflurane?
MediHelp rates the interaction as major. Givinostat and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval, and its labeling advises caution with other QT-prolonging drugs. Sevoflurane adds to this effect and may raise the risk of torsades de pointes.
How serious is the interaction between Givinostat and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before anesthesia and keep potassium and magnesium within normal range. Monitor the ECG during and after anesthesia, and withhold givinostat if QTc becomes markedly prolonged.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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