Drug interactions
Glasdegib + Ondansetron
Severity: Moderate
Glasdegib and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval and ondansetron has the same effect. Together they may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Glasdegib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium. Consider another antiemetic if the QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Ondansetron?
MediHelp rates the interaction as moderate. Glasdegib and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval and ondansetron has the same effect. Together they may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Glasdegib and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium. Consider another antiemetic if the QTc lengthens substantially.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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