Drug interactions
Glasdegib + Sotalol
Severity: Major
Glasdegib and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval and sotalol carries a substantial risk of torsades de pointes. Combined use may increase the risk of dangerous ventricular arrhythmia.
What this interaction means in plain words
Glasdegib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic prolongation of ventricular repolarization.
What to do
Use an alternative if feasible; otherwise monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glasdegib and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Sotalol?
MediHelp rates the interaction as major. Glasdegib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib can prolong the QT interval and sotalol carries a substantial risk of torsades de pointes. Combined use may increase the risk of dangerous ventricular arrhythmia.
How serious is the interaction between Glasdegib and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative if feasible; otherwise monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium abnormalities.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
