Drug interactions
Glatiramer + Leflunomide
Severity: Minor
Glatiramer and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glatiramer is an immunomodulator rather than a broadly immunosuppressive drug and is not clearly linked to serious infection. Any added risk with leflunomide is mostly attributable to leflunomide itself.
What this interaction means in plain words
Glatiramer and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glatiramer belongs to Central Nervous System; Leflunomide belongs to Musculoskeletal.
Why it happens
No well-established interaction mechanism; theoretical additive immune modulation.
What to do
No specific adjustment is needed; continue standard leflunomide monitoring of blood counts and liver enzymes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Glatiramer
- Anakinra + Glatiramer Minor
- Anti-thymocyte + Glatiramer Minor
- Basiliximab + Glatiramer Minor
- Denosumab + Glatiramer Minor
- Echinacea + Glatiramer Minor
- Etanercept + Glatiramer Minor
Frequently asked questions
Can I take Glatiramer with Leflunomide?
MediHelp rates the interaction as minor. Glatiramer and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glatiramer is an immunomodulator rather than a broadly immunosuppressive drug and is not clearly linked to serious infection. Any added risk with leflunomide is mostly attributable to leflunomide itself.
How serious is the interaction between Glatiramer and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed; continue standard leflunomide monitoring of blood counts and liver enzymes.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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