Drug interactions
Glecaprevir / pibrentasvir + Ivermectin
Severity: Minor
Glecaprevir / pibrentasvir and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir inhibit P-glycoprotein and could increase ivermectin exposure. Ivermectin's broad safety margin makes a clinically significant effect unlikely.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases ivermectin absorption.
What to do
No dose adjustment is generally needed. Monitor for increased ivermectin adverse effects such as dizziness or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glecaprevir / pibrentasvir and Ivermectin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ivermectin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both glecaprevir and pibrentasvir inhibit P-glycoprotein and could increase ivermectin exposure. Ivermectin's broad safety margin makes a clinically significant effect unlikely.
How serious is the interaction between Glecaprevir / pibrentasvir and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for increased ivermectin adverse effects such as dizziness or gastrointestinal upset.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
