Drug interactions
Glecaprevir / pibrentasvir + Leflunomide
Severity: Moderate
Glecaprevir / pibrentasvir and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit BCRP and may raise teriflunomide concentrations. Higher exposure could increase the risk of hepatotoxicity and bone marrow suppression, which is particularly relevant in patients being treated for hepatitis C.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of BCRP efflux transport increases teriflunomide exposure.
What to do
Monitor liver function tests and blood counts during combined therapy. Reduce the leflunomide dose or stop it if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glecaprevir / pibrentasvir and Leflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Leflunomide?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit BCRP and may raise teriflunomide concentrations. Higher exposure could increase the risk of hepatotoxicity and bone marrow suppression, which is particularly relevant in patients being treated for hepatitis C.
How serious is the interaction between Glecaprevir / pibrentasvir and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and blood counts during combined therapy. Reduce the leflunomide dose or stop it if toxicity develops.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
