Drug interactions
Glecaprevir / pibrentasvir + Posaconazole
Severity: Moderate
Glecaprevir / pibrentasvir and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase glecaprevir and pibrentasvir exposure, and the combination may also raise posaconazole levels. Clinically significant effects are not well characterized, but hepatic tolerability of the HCV regimen is the main concern.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4 and P-gp, and glecaprevir and pibrentasvir inhibit P-gp, which may reduce efflux of each other's substrates.
What to do
Monitor liver function tests and for adverse effects of both agents. No empirical dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Posaconazole?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase glecaprevir and pibrentasvir exposure, and the combination may also raise posaconazole levels. Clinically significant effects are not well characterized, but hepatic tolerability of the HCV regimen is the main concern.
How serious is the interaction between Glecaprevir / pibrentasvir and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for adverse effects of both agents. No empirical dose change is required.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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