Drug interactions
Glecaprevir / pibrentasvir + Progesterone
Severity: Minor
Glecaprevir / pibrentasvir and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone may weakly inhibit P-glycoprotein and slightly raise glecaprevir/pibrentasvir exposure. The effect is expected to be small.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone may inhibit P-glycoprotein efflux of glecaprevir and pibrentasvir.
What to do
No routine adjustment is needed; be aware of this interaction when interpreting adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Progesterone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone may weakly inhibit P-glycoprotein and slightly raise glecaprevir/pibrentasvir exposure. The effect is expected to be small.
How serious is the interaction between Glecaprevir / pibrentasvir and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware of this interaction when interpreting adverse effects.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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