Drug interactions
Glibenclamide + Sodium zirconium cyclosilicate
Severity: Minor
Glibenclamide and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH temporarily, which may change the absorption of drugs with pH-dependent solubility. Glyburide's absorption could be altered, though the clinical effect is uncertain.
What this interaction means in plain words
Glibenclamide and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Transient increase in gastric pH may alter dissolution and absorption of glyburide.
What to do
Give glyburide at least 2 hours before or after sodium zirconium cyclosilicate. Monitor glucose if the dosing schedule changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Glibenclamide with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Glibenclamide and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can raise gastric pH temporarily, which may change the absorption of drugs with pH-dependent solubility. Glyburide's absorption could be altered, though the clinical effect is uncertain.
How serious is the interaction between Glibenclamide and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glyburide at least 2 hours before or after sodium zirconium cyclosilicate. Monitor glucose if the dosing schedule changes.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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