Drug interactions
Gliclazide + Hydrochlorothiazide
Severity: Moderate
Gliclazide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of gliclazide, particularly at higher doses. Thiazide-induced hypokalemia may impair insulin secretion.
What this interaction means in plain words
Gliclazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism via hypokalemia, reduced insulin release and decreased insulin sensitivity.
What to do
Monitor blood glucose and serum potassium, and adjust the antidiabetic regimen if control worsens. Use the lowest effective thiazide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Gliclazide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Gliclazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of gliclazide, particularly at higher doses. Thiazide-induced hypokalemia may impair insulin secretion.
How serious is the interaction between Gliclazide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust the antidiabetic regimen if control worsens. Use the lowest effective thiazide dose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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