Drug interactions
Gliclazide + Leriglitazone
Severity: Moderate
Gliclazide and Leriglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leriglitazone improves insulin sensitivity while gliclazide stimulates insulin secretion, so combined use raises the risk of hypoglycaemia.
What this interaction means in plain words
Gliclazide and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Leriglitazone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic glucose-lowering effects through insulin sensitisation and secretion.
What to do
Monitor blood glucose closely at initiation and after dose changes, and reduce the gliclazide dose if hypoglycaemia occurs. Counsel the patient on hypoglycaemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
- Lapatinib + Leriglitazone Moderate
Other interactions of Gliclazide
Frequently asked questions
Can I take Gliclazide with Leriglitazone?
MediHelp rates the interaction as moderate. Gliclazide and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leriglitazone improves insulin sensitivity while gliclazide stimulates insulin secretion, so combined use raises the risk of hypoglycaemia.
How serious is the interaction between Gliclazide and Leriglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely at initiation and after dose changes, and reduce the gliclazide dose if hypoglycaemia occurs. Counsel the patient on hypoglycaemia symptoms.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
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