Drug interactions
Itraconazole + Leriglitazone
Severity: Moderate
Itraconazole and Leriglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A inhibitor that may raise leriglitazone concentrations. Increased exposure may worsen fluid retention and other dose-related effects.
What this interaction means in plain words
Itraconazole and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Leriglitazone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 reduces leriglitazone metabolism.
What to do
Avoid if possible; otherwise monitor for fluid retention, weight gain and glucose, and consider reducing the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
- Lapatinib + Leriglitazone Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Leriglitazone?
MediHelp rates the interaction as moderate. Itraconazole and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A inhibitor that may raise leriglitazone concentrations. Increased exposure may worsen fluid retention and other dose-related effects.
How serious is the interaction between Itraconazole and Leriglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for fluid retention, weight gain and glucose, and consider reducing the dose.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
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