Drug interactions
Carbamazepine + Leriglitazone
Severity: Moderate
Carbamazepine and Leriglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A and CYP2C8 and can lower leriglitazone concentrations, reducing its effect.
What this interaction means in plain words
Carbamazepine and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Leriglitazone belongs to Central Nervous System.
Why it happens
Enzyme induction increases leriglitazone metabolic clearance.
What to do
Avoid if possible and consider a non-inducing anticonvulsant. If combined, monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
- Lapatinib + Leriglitazone Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Leriglitazone?
MediHelp rates the interaction as moderate. Carbamazepine and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A and CYP2C8 and can lower leriglitazone concentrations, reducing its effect.
How serious is the interaction between Carbamazepine and Leriglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and consider a non-inducing anticonvulsant. If combined, monitor clinical response.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Clarithromycin, Gliclazide. The full list is on the Leriglitazone page.
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