Drug interactions
Clarithromycin + Leriglitazone
Severity: Moderate
Clarithromycin and Leriglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A inhibitor and may increase leriglitazone exposure, raising the chance of dose-related adverse effects.
What this interaction means in plain words
Clarithromycin and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Leriglitazone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 reduces leriglitazone metabolism.
What to do
Use an alternative antibiotic such as azithromycin where suitable. If clarithromycin is needed, monitor for fluid retention and glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
- Lapatinib + Leriglitazone Moderate
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Leriglitazone?
MediHelp rates the interaction as moderate. Clarithromycin and Leriglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin is a strong CYP3A inhibitor and may increase leriglitazone exposure, raising the chance of dose-related adverse effects.
How serious is the interaction between Clarithromycin and Leriglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic such as azithromycin where suitable. If clarithromycin is needed, monitor for fluid retention and glucose.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Gliclazide. The full list is on the Leriglitazone page.
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