Drug interactions
Gemfibrozil + Leriglitazone
Severity: Major
Gemfibrozil and Leriglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil strongly inhibits CYP2C8, the main metabolic route for glitazones such as leriglitazone. Exposure increases, raising the risk of adverse effects such as fluid retention and hypoglycaemia.
What this interaction means in plain words
Gemfibrozil and Leriglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Leriglitazone belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 decreases leriglitazone clearance.
What to do
Avoid the combination and use a different lipid-lowering drug. If unavoidable, monitor for oedema, heart failure signs and glucose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leriglitazone
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
- Lapatinib + Leriglitazone Moderate
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Leriglitazone?
MediHelp rates the interaction as major. Gemfibrozil and Leriglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil strongly inhibits CYP2C8, the main metabolic route for glitazones such as leriglitazone. Exposure increases, raising the risk of adverse effects such as fluid retention and hypoglycaemia.
How serious is the interaction between Gemfibrozil and Leriglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different lipid-lowering drug. If unavoidable, monitor for oedema, heart failure signs and glucose.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Carbamazepine, Clarithromycin, Gliclazide. The full list is on the Leriglitazone page.
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