Drug interactions
Gliclazide + Levoketoconazole
Severity: Moderate
Gliclazide and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP enzymes including CYP2C9, which contributes to gliclazide metabolism, so gliclazide exposure may rise. This can lead to prolonged or severe hypoglycemia.
What this interaction means in plain words
Gliclazide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 (and CYP2C19) mediated gliclazide metabolism.
What to do
Monitor blood glucose closely after starting or stopping levoketoconazole and reduce the gliclazide dose if hypoglycemia occurs. Consider an alternative antidiabetic if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Gliclazide with Levoketoconazole?
MediHelp rates the interaction as moderate. Gliclazide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP enzymes including CYP2C9, which contributes to gliclazide metabolism, so gliclazide exposure may rise. This can lead to prolonged or severe hypoglycemia.
How serious is the interaction between Gliclazide and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting or stopping levoketoconazole and reduce the gliclazide dose if hypoglycemia occurs. Consider an alternative antidiabetic if control is unstable.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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