Drug interactions
Gliclazide + Linagliptin
Severity: Moderate
Gliclazide and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to a sulfonylurea increases the risk of hypoglycemia because the sulfonylurea continues to drive insulin secretion. The effect is glucose-dependent for linagliptin but not for gliclazide.
What this interaction means in plain words
Gliclazide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering via DPP-4 inhibition and sulfonylurea-induced insulin release.
What to do
Consider reducing the gliclazide dose when starting linagliptin. Monitor blood glucose and educate the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Linagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Gliclazide with Linagliptin?
MediHelp rates the interaction as moderate. Gliclazide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to a sulfonylurea increases the risk of hypoglycemia because the sulfonylurea continues to drive insulin secretion. The effect is glucose-dependent for linagliptin but not for gliclazide.
How serious is the interaction between Gliclazide and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the gliclazide dose when starting linagliptin. Monitor blood glucose and educate the patient on hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
