Drug interactions
Gliclazide + Lopinavir
Severity: Moderate
Gliclazide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can cause insulin resistance and hyperglycemia, opposing the effect of gliclazide. Metabolic effects on gliclazide levels are also possible but unpredictable.
What this interaction means in plain words
Gliclazide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-related insulin resistance, with possible variable CYP effects on sulfonylurea metabolism.
What to do
Monitor blood glucose when starting or stopping lopinavir and adjust the antidiabetic regimen according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Gliclazide with Lopinavir?
MediHelp rates the interaction as moderate. Gliclazide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can cause insulin resistance and hyperglycemia, opposing the effect of gliclazide. Metabolic effects on gliclazide levels are also possible but unpredictable.
How serious is the interaction between Gliclazide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lopinavir and adjust the antidiabetic regimen according to results.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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