Drug interactions
Gliclazide + Metolazone
Severity: Moderate
Gliclazide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce the glucose-lowering effect of gliclazide. Potassium loss may further impair insulin release.
What this interaction means in plain words
Gliclazide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism via diuretic-induced hypokalemia reducing insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose and serum potassium when metolazone is started or its dose changed. Increase the antidiabetic dose if needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Metolazone
Frequently asked questions
Can I take Gliclazide with Metolazone?
MediHelp rates the interaction as moderate. Gliclazide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce the glucose-lowering effect of gliclazide. Potassium loss may further impair insulin release.
How serious is the interaction between Gliclazide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when metolazone is started or its dose changed. Increase the antidiabetic dose if needed and correct hypokalemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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